After a long process of development of teaching and scientific disciplines, which are today within its scope of activity, and through a rich history of its development, the Department of Invertebrate Zoology and Entomology was founded on 24.12.2010. at the Institute of Zoology. A great contribution to the modernization of zoology teaching, after 1873, at the time of the formation of the Department of Zoology within the Zoological Institute (the predecessor of today's Institute of Zoology), was made by Prof. Dr. Živojin Đorđević, and somewhat later (between the two world wars) by Prof. Dr. Siniša Stanković. After the Second World War, in 1947, the Department of Zoology and Physiology was formed, and somewhat later a separate Department of Zoology was created from it. The most notable activities at that department were by Prof. Dr. Milutin Radovanović and Prof. Dr. Simeon Grozdanić.

Later, in the 1970s, with the development of zoological disciplines at the Institute of Zoology, the Department of Comparative Morphology and Systematics of Animals was founded, which was renamed the Department of Morphology, Systematics and Phylogeny of Animals in 2002. Teachers and associates who teach courses whose subject of research is invertebrates, and especially insects, founded the current Department of Invertebrate Zoology and Entomology in 2010. Today, this department has six teachers, eight research associates, one research associate, two research interns and one technical associate, research intern and technical associate. From its founding until 2017, the department was headed by Prof. Dr. Ljubiša Stanisavljević, and after him Prof. Dr. Ivana Živić.

In the period from the 1970s to the end of 2010, the teachers and associates of the Department taught undergraduate, postgraduate and doctoral studies within the departments to which they belonged until the establishment of the new department. Until the end of the 20th century, they taught invertebrate zoology subjects within the elective field "Morphology, systematics and phylogeny of zoological taxa". With the reform of 2002, a separate scientific field "Morphology, systematics and phylogeny of invertebrates" was separated from several narrower areas of research ("Entomology", "Malacology", "Helmintology", "Acarology"). Teachers and associates of the Department participated in the implementation of postgraduate studies ("Taxonomy and Phylogeny of Animals" and "Beekeeping" until 1998), and later also master's studies ("Morphology, Systematics and Phylogeny of Animals", "Entomology" and "Biology of Bees with Beekeeping"). In addition to theoretical and practical teaching, the Department also implements field teaching at undergraduate and master's studies (Fruška Gora, Avala, Research Station, Petnica).

Since the 2011/12 academic year, the Department's teachers and associates have been participating in teaching according to the reformed system of study within the framework of basic academic studies in two core and a larger number of elective subjects. Since the same academic year, the Department has been implementing its own module of master's academic studies "Invertebrate Zoology and Entomology", and later, since the 2016/17 academic year, in cooperation with two other departments, it has been implementing the master's module "Zoology". Since the 2006/07 academic year, the Department's teachers have been participating in the implementation of teaching in doctoral studies in the modules "Morphology, systematics and phylogeny of animals" and "Hydrobiology", and since the 2010/11 academic year in its own submodule "Entomology", which has been implemented as a module since the 2016/17 academic year.

The scientific work of the teachers and associates of the Department takes place within the scientific field "Morphology, systematics and phylogeny of animals", which has been changed to the scientific field of Zoology since 2019. The narrower scientific areas of research of the members of the Department are systematics, phylogeny, diversity, ecology, faunistics, taxonomy and population biology of parasitoids and pollinators, coleopterans, soil, cavernicolous and aquatic invertebrates (using morphological characters and molecular markers), applied entomology (metapopulation models, parasitoid-host and predator-prey interactions, biological control and monitoring of economically harmful insect species, domestication of solitary bees), monitoring the activity of antioxidant enzymes as indicators of the antioxidant status of aquatic invertebrates and biomarkers of oxidative stress in aquatic ecosystems, determination of functional groups aquatic invertebrate nutrition, monitoring the accumulation and distribution of heavy metals in water, sediment and aquatic invertebrates, insect photonics, biomimetics, chemoecology, chemotaxonomy, analysis of various biological effects (antimicrobial, antitumor and cytotoxic) of pygidial gland secretions of honeybees, testing the content of metals and metalloids, measuring organic pollutants (pesticides, PAHs, etc.) in bees and their organs.