The Center for Laser Microscopy (CLM) was established in 2004. The head since its establishment has been Prof. Pavle R. Andjus.

The main initial funds for the development of the Center were obtained through the EU FP6 project "NEUROIMAGE" (the first biomedical project of its kind conducted in Serbia) and partly from the Ministry of Science and Environmental Protection. Since its establishment, the CLM has developed rapidly, as can be seen through numerous scientific projects (25), high-level publications (~70) and 7 PhDs of associates. International cooperation of the CLM has occupied a special place since its establishment. Currently, the Center is leading one EU Horizon 2020 project ("AUTOIGG") and is participating as a partner in the Horizon-EU project "BioQantSense".

The Center's scientific excellence is reflected in the biophysical profiling of molecular and cellular markers in in vitro (cell culture) and in vivo disease models (transgenic animals) using modern biophysical techniques based on live cell imaging (video and confocal microscopy), electrophysiology and various immunohistochemical approaches. In recent years, the Center has been engaged in the development of an innovative biomedical device for precise in vitro diagnostics of neuroinflammatory diseases, based on microfluidic lab-on-a-chip technology for measuring and decoding fluorescent biosignals. The Center also conducts demonstration exercises in advanced microscopy techniques for students of all levels of study. The Center has also been the organizer of several international schools of imaging in biomedicine, especially advanced fluorescence microscopy techniques.